- The only previous UEFA competition matches between these teams were in the 2017/18 Champions League group stage when a 3-1 home victory for Barcelona on Matchday 3 was followed by a 0-0 draw in Greece on Matchday 4.
- Barcelona have won all their previous seven home matches in UEFA competition against Greek teams.
- Lamine Yamal (18 years 100 days) could become the youngest player to make 25 appearances in the Champions League proper. The current youngest is Warren Zaïre-Emery (19 years 32 days).
- Olympiacos are without a win in their previous 16 away matches against Spanish teams in UEFA competition (D2 L14) and have lost their last 11 Champions League group stage/league phase matches away from home.
- The Greek outfit have won only two of their last 22 Champions League group stage/league phase matches (D3 L17). However, the Piraeus club have kept seven clean sheets in their last 11 European games.
- Olympiacos midfielder Daniel Podence could make an appearance on his 30th birthday.
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